The Curator's Office is located on in the Hall of Heroes, and can be accessed through the Cultural Arts Hallway or the Staff Barracks.
This room holds most of the museum's interactive stations.
One of the most important stations is the Display Prep Station. It is a table with lots of different things on it, like statues and display cases. When you click on the station, it will automatically sort all available museum items from your inventory to their display spots in the museum. It has a few setting for ignoring quest items and preffering replica's or the orignal item when sorting.
Another important station is the Replica Station. As the name implies, the replica station can be used to make replicas of items. Quest books, scrolls and the like will need to be replicated at the Scribe's Desk which is accessed by sitting down on the chair in front of the desk. As long as you have had the original relic in your inventory, you will be able to craft it, even after it is handed in, so there is no need to craft a replica before you complete the quest associated with the original relic. All replicas require different resources to craft.
The Archaeology Station can be used to make item from your archeological fragments.
Above the replica station is a shelf with two mannequins and a small chest. Clicking the mannequins will bring up the mannequin choice menu, where you can choose whether you want only male mannequins or a mixture of male and female mannequins throughout the museum (male and female mix is the default). The chest and the crate next to it can be used to acces your supplies, using the Craftloot system.
There's a stand where the Museum Armor Cuirass, Museum Armor Gloves and Museum Armor Boots can be taken. Next to it is a display spot for Auryen Morellus's sword, Aedrasorn, which can not be taken out of it's display by anyone other than Auryen. The notes that start the quest will be around the Scribe's Desk.
There's a picture called Keeper of Secrets. Behind it is the Museum Safe. In here all items displayed in the museum will be stored.
There is also a Shipment Planner and a crate for Museum Shipments. These can be used to activate shipping containers all across Skyrim, which you can use to send item to the museum.